Publications by Researchers (2010 - 2015)

Yarlett group:

Morada M, Weiss L, Gunther-Cummins L, & Yarlett N. Use of Hollow Fiber Technology Simulates Intestinal Development and Permits Continuous Culture of Cryptosporidium parvum. Int. J. Parasitol.  (submitted 2015).   

O’Sullivan MC, Durham TB, Valdes HE, Dauer KI, Karney NJ, Forrestel AC, Bacchi CJ, Baker JF, (2015) Dibenzosuberyl substituted polyamines and analogs of clorimpramine as effective inhibitors of trypanothione reductase; molecular docking and assessment of trypanocidal activities. Bioorg. Med. Chem. 23:996-1010.

Williams C, Yarlett N, Aon MA, & Lloyd D. (2014) Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol. Mol Biochem Parasitol 196 (1):45-52.

Mittal N, Morada M, Tripathi P, Gowri VS, Mandal S, Quirch A,* Park MH, Yarlett N, & Madhubala R (2014) Cryptosporidium parvum has an active hypusine biosynthesis pathway. Mol. Biochem. Parasitol. 195:14-22.

Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, & Don R (2014) Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaborales in the treatment of Stage 2 Human African Trypanosomiasis. Parasitology 141:104-118

Kirchoff LV, Bacchi CJ, Machado FS, Garg NJ, Huang H, Mukherjee S, Weiss LM, Tanowitz HB. (2014) Trypanosomes, in Reference module in biomedical research. Chapter 02480. Elsevier:New York, pp1-17. 

Morada M, Pendyala L, Wu G, Merali S, & Yarlett N (2013) Cryptosporidium parvum induces an endoplasmic stress response in the intestinal adenocarcinoma HCT-8 cell line. J. Biol. Chem. 288:30356-30364.

Bacchi C, Jacobs R, & Yarlett N. (2013) New Developments in the Treatment of Late-Stage Human African Trypanosomiasis. In: Trypanosomatid Diseases Molecular Routes to Drug Discovery. T. Jager, O. Koch, L. Flohe (eds). Drug Discovery in Infectious Diseases Vol 4, Wiley-Blackwell:515-529.

Levandowsky, M. Physiological adaptations of protozoa (2012). Cell Physiology Sourcebook, (Ed. N. Sperelakis) . pp. 874 – 894. Academic Press, Elsevier. London, UK

Rubenstein, D., Prum, R., Levandowsky,M. (Eds.) (2012). Sexual Selection, Social Conflict and the Female Perspective. Themed Issue, Phil.Trans. Roy. Soc B, 367, 2248-2375.

Yarlett N & Morada M. (2012) Antiparasitic Drug Discovery for the Polyamine Pathway. In: Polyamine Drug Discovery. P. Woster & R. Casero Jr. (eds). RSC Drug Discovery Series No. 17. Royal Society of Chemistry pub.

Jacobs RT, Plattner JJ, Nare B, Wring S, Chen D, Freund Y, Gaukel EG, Orr MD, Perales JB, Jenks M, Noe RA, Sligar J, Zhang Y-K, Bacchi C, Yarlett N, & Don R (2011) Benzoxaborales: a new class of potential drugs for the treatment of human African trypanosomiasis. Future Med. Chem. 3:1259-1278.

Mercer L, Bowling T, Perales J, Freeman J, Nguyen TM, Bacchi CJ, Yarlett N, Don R, Jacobs R, & Nare B. (2011) 2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. Plos Neg Trop Dis. 5:e956.

Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang Y-K, Brun R, Kaiser M, Scandale I, Don R. (2011) SCYX-7158, an orally active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl. Trop. Dis. 5:1-11. 

Perales JB, Freeman J, Bacchi CJ, Bowling T, Don R, Gaukel E, Mercer L, Moore III JA, Nare B, Nguyen TM, Noe RA, Randolph R, Rewarts C, Wring S, Yarlett N, & Jacobs R. (2011) SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei. Bioorg Med Chem Letts. 21:2816-2819.

Mayence A, Vanden Eynde JJ, Kaiser M, Brun R, Yarlett N, & Huang TL. (2011) Bis(oxyphenylene) benzimidazoles: A novel class of anti-Plasmodium falciparum agents. Bioorg Med Chem. 19:7493-7500.

Nare B, Wring S, Bacchi C, Beaudet B, Bowling T, Brun R, Chen D, Ding C, Freund Y, Gaukel E, Hussain A, Jarnagin K, Jenks M, Kaiser M, Mercer L, Mejia E, Noe A, Orr M, Parham R, Plattner J, Randolph R, Rattendi D, Rewerts C, Sligar J, Yarlett N, Don R, & Jacobs R. (2010). Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system African trypanosomiasis. Antimic Ag & Chemother. 54:4379-4388.

Morada M, Smid O, Hampl V, Sutak R, Lam B, Rappelli P, Dessi D, Fiori PL, Tachezy J, & Yarlett N. (2011) Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis. Mol Biochem Parasitol. 176:51-54.

Ding D, Zhao Y, Meng Q, Xie S, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang Y-K, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang K-H, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, & Plattner JJ (2010) Discovery of novel benzoxaborole-based potent antitrypanosomal agents. Am. Chem. Soc. Med. Letts. 1:165-169.

Morada M, Manzur M, Lam B, Tan C, Tachezy J, Rappelli P, Dessi D, Fiori PL, & Yarlett N. (2010) Arginine metabolism in Trichomonas vaginalis infected with Mycolplasma hominis. Microbiology. 156:3734-3743.

Upmacis group:

Palmer JH, Wu J,* & Upmacis RK. (2015) Coordination of metronidazole to Cu(II): Structural characterization of a mononuclear square-planar compound.  Journal of Molecular Structure, Available online 24 February, In Press, Accepted Manuscript.

Rozov M,* Brescia TK,* Valdez L.* & Upmacis RK. (2015) Teaching Green Chemistry principles to undergraduate students.  Accepted as a Conference Paper and also a Journal Paper.  The Athens Institute for Education and Research (ATINER) Conference Paper Series PHY-CHE-2013-0880.  Athens Journal of Science, In Press, Accepted Manuscript.

 Palmer JH. & Upmacis RK. (2015) Crystal structure of bis[1-(2-hydroxyethyl)-2-methyl-5-nitro-1H-imidazole-κN3]silver(I) tetrafluoridoborate methanol monosolvate.  Acta Crystallographica, E71:284-287.

 Jordan KD.* & Upmacis RK. (2013) Mass spectrometric analysis of oxidized eicosapentaenoic acid sodium salt.  Lipid Insights, 6:21-35.

Upmacis RK, Shen H, Benguigui LES., Brian D, Lamon, BD, Hajjar KA. & Hajjar DP. (2011) Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice.  American Journal of Physiology Heart and Circulatory Physiology, 301:H617-24.

Lamon BD, Upmacis RK, Deeb RS, Koyuncu H & Hajjar DP.  (2010) Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli.  American Journal of Physiology Heart and Circulatory Physiology, 299:H613-23.

Deeb RS, Cheung C, Nuriel T, Lamon BD, Upmacis RK, Gross SS & Hajjar DP.  (2010) Physical evidence for substrate in preservation of cyclooxygenase function under nitrative stress.  Journal of American Chemical Society, 132:3914-22.

Drosopoulos JHF, Kraemer R, Shen H, Upmacis RK, Marcus AJ & Musi E. (2010) Human SolCD39 inhibits injury-induced development of neointimal hyperplasia.  Thrombosis and Haemostasis, 103:426-34.

Chan group:

Chan C, Joseph I, Huang A, Jackson D & Lipke P. Quantitative analyses of force-induced amyloid formation in Candida albicans Als5p: activation by standard laboratory procedures. PlosOne (submitted 2015).

Chan C & Lipke P (2014). Role of force-sensitive amyloid-like interactions in fungal catch-bonding and biofilms. Eukaryotic Cell 13:1136-1142.

Lipke P, Ramsook C, Garcia-Sherman M, Jackson D, Chan C, Bois M, & Klotz S (2014). Between amyloids and aggregation lies a connection with strength and adhesion. New Journal of Science 815, 102.

Mickley A, * Carney P, * Isaacman M, Tan C & Dai Z (2011). Syntheses of chiroptical fluorescent ligands for the detection of mercury. Asian Journal of Chemistry 23:2852-2856.

Morada M, Manzur M,* Lam B, Tan C, Tachezy J, Rappelli P, Dessì D, Fiori PL & Yarlett N (2010). Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis. Microbiology 156 (Pt 12):3734-43.

Ramsook CB, Tan C, Garcia MC, Fung R, Soybelman G, Henry R, Litewka A, O'Meally S, Otoo HN, Khalaf RA, Dranginis AM, Gaur NK, Klotz SA, Rauceo JM, Jue CK & Lipke PN (2010). Yeast cell adhesion molecules have functional amyloid-forming sequences. Eukaryotic Cell 9(3):393-404.

Frank AT, Ramsook CB, Otoo HN, Tan C, Soybelman G, Rauceo JM, Gaur NK, Klotz SA & Lipke (2010). Structure and function of glycosylated tandem repeats from Candida albicans Als adhesins. Eukaryotic Cell 9(3):405-14.

Levandowsky group:

Hoquet T & Levandowsky M. (2015) Utility vs Beauty: Darwin, Wallace and the Subsequent History of the Debate on Sexual Selection.  Current Perspectives on Sexual Selection, History, Philosophy and Theory of the Life Sciences 9:19-44.